Factory Supply Lithium Orotate, CAS No. 5266-20-6
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|Min. Order:||1 kg|
|Production Capacity:||500mt Per Year|
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- Model NO.: DP-125
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >98%
- Heavy Metals: 20ppm Max
- Specification: 98.5%
- Powder: Yes
- Certification: ISO 9001
- State: Solid
- Loss on Drying: 0.5% Max
- Trademark: N/M
- Origin: China
|Product Name||Lithium orotate|
Lithium orotate, is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion. It is marketed as a dietary supplement, though only barely researched between 1973-1986 to treat certain medical conditions, such as alcoholism, and Alzheimer's disease.
Lithium is a mineral with a cloudy reputation. It is an alkali metal in the same family as sodium, potassium and other elements. Although lithium is highly effective in the treatment of manic depressive illness (X4 DI), its pharmaceutical (prescription) versions - lithium carbonate and lithium citrate - must be used with caution. (1) The reason for the caution with prescription lithium is because lithium in these forms is poorly absorbed by the cells of the body - and it is within the cells that lithium's therapeutic effects take place. Lithium ions are believed to act only at particular sites on the membranes of intracellular structures like mitochondria and lysosomes.
Consequently, because of this poor intracellular transport, high dosages of pharmaceutical forms of lithium must be taken in order to obtain a satisfactory therapeutic effect. Unfortunately, these therapeutic dosages cause blood levels to be so high that they border on toxic levels. Consequently, patients taking prescription lithium must be closely monitored for toxic blood levels. Serum lithium and serum creatinine levels of prescription lithium-treated patients should be monitored every 3-6 months.
Lithium orotate is a dietary supplement that can be used in small doses to treat conditions like manic depression, alcoholism, ADHD and ADD, depression, aggression, PTSD, Alzheimer's Disease and overall stress management.
Superiority of Lithium Orotate
The lithium salt of orotic acid (lithium orotate) improves the specific effects of lithium many-fold by increasing lithium bio-utilization. The orotates transport the lithium to the membranes of mitochondria, lysosomes and the glia cells. Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts.
Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium. For example, in cases of severe depression, the therapeutic dosage of lithium orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse lithium side reactions and no need for monitoring blood serum measurements.
Other Uses for Lithium Orotate
Lithium orotate has also been used with success in alleviating the pain from migraine and cluster headaches, low white blood cell counts, juvenile convulsive disease, alcoholism and liver disorders. (18) Nieper also reports that patients with myopia (nearsightedness) and glaucoma often benefit from the slight dehydrating effect of lithium on the eye, resulting in improvement in vision and reduction of intraocular pressure.
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