- Model NO.: DP-132
- Assay Method: HPLC
- Application: Health Care Products
- Extract Source: Aole Ferox Miller
- Specification: 98%, 95%
- Certification: ISO
- Application Form: Paste, Tablet, Capsule
- State: Powder
- Trademark: N/M
- Origin: China
|Active Ingredients||Aloe emodin|
|Appearance||brown-yellow fine powder|
|Botanical Source||Derived aloin synthesis|
Aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Taking into account its unique cytotoxicity profile and mode of action, AE might represent a conceptually new lead antitumor drug.
1. Anti-tumor activity
2. Aloe-emodin on the inhibition of P388 leukemia cells and prolong survival. One of the mechanisms is the inhibition of cancer cell DNA, RNA and protein biosynthesis.
3. Antibacterial activity
4. Immunosu ppression
5. Aloe-emodin can inhibit the organisms immune response, inhibition of carbon clearance ability, to reduce the weight of immune organs, reduced white blood cell count, decreased macrophage function. 100μg/ml concentration in vitro [3H]-TDR and [3H] Urd into the cell parameters significantly inhibited.
6. Purgative activity
7. Aloe-emodin has a strong purgative activity of intestinal bacteria metabolism aloe emodin, rhein, rhein anthrone, which has a strong purgative effect.
1. Applied in food additives, it is used as nutritious supplementary pharmaceutical.
2. Applied in pharmaceutical field, it is used to treating constipation and expelling of toxin and treating.
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